This increase in QAlb levels means that male patients are more likely to receive a laboratory report suggesting altered CSF protein content and functional impairment of BCSFB with respect to females. These data were confirmed in neurological patients, psychiatric subjects, as well as in healthy individuals.
It has emerged that QAlb is higher in males than females regardless of age as a consequence of a reduced CSF-flow rate (e.g., an increased transfer of protein from blood to CSF, reduced CSF elimination from CSF space into lymphatic organs or venous compartment) in the male sex. In recent years, the existence of sexual dimorphism at the level of CSF protein content has become increasingly evident, and in particular, these sex-related differences seem to concern all the concentrations of plasma-derived proteins. (4) Discussion: Although the main difference between males and females concerns the function of BCSFB assessed by QAlb, this sexual dimorphism does not affect the determination of the IIS evaluated both by quantitative and qualitative methods. No differences emerged for quantitative and qualitative IIS determinations. Age was positively correlated to disease duration and severity in MS ( r = 0.3502, r = 0.2986, respectively). In CIS patients, QAlb increased with age only in males ( r = 0.3567). 4.34) and correlated to age with a constant difference between sexes (F = 41.71).
(3) Results: In MS, the albumin quotient (QAlb), reflecting the blood–CSF barrier (BCSFB) function, was higher in males (5.6 vs. (2) Methods: Clinical and laboratory data from 340 MS patients (F = 231, M = 99) and 89 people with clinically isolated syndrome (CIS) (F = 57, M = 32) were retrospectively analyzed to assess the presence of variables affected by sex and age. A sexual dimorphism has recently been described in CSF protein content. The detection of intrathecal IgG synthesis (IIS) on cerebrospinal fluid (CSF) analysis supports the diagnosis of MS. (1) Background: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) that mainly affects young adults and females more than males.
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